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Nelarabine (Arranon)

Catalog No.: A10632

Nelarabine (Arranon)

Nelarabine (Arranon) Chemical Structure

CAS NO. 121032-29-9

Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
50 mg
$400.00
100 mg
$580.00
10mM * 1mL in DMSO
$80.00
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Biological Activity

Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity.
Targets
DNA synthesis (PER-255 cells) DNA synthesis (HSB2 cells) DNA synthesis (ALL-SIL cells) DNA synthesis (JURKAT cells)
67 nM0.44 μM1.24 μM2.15 μM
In vitro (25°C) DMSO 55 mg/mL (185.01 mM)
Water 3 mg/mL (10.09 mM)
Ethanol Insoluble
In vivo saline 2 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.64 mL 168.18 mL 336.36 mL
0.5 mM 6.73 mL 33.64 mL 67.27 mL
1 mM 3.36 mL 16.82 mL 33.64 mL
5 mM 0.67 mL 3.36 mL 6.73 mL

*The above data is based on the productmolecular weight 297.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10632
CAS No. 121032-29-9
Formula C11H15N5O5
M. Wt 297.3
Purity >98%
Synonyms 506U78
SMILES COC1=NC(=NC2=C1N=CN2[[email protected]]3[[email protected]]([[email protected]@H]([[email protected]](O3)CO)O)O)N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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