Nelarabine (Arranon)

Catalog No.: A10632

Nelarabine (Arranon) Chemical Structure

CAS NO. 121032-29-9

Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
50 mg
$400.00
100 mg
$580.00
10mM * 1mL in DMSO
$80.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity.
Targets
DNA synthesis (PER-255 cells) DNA synthesis (HSB2 cells) DNA synthesis (ALL-SIL cells) DNA synthesis (JURKAT cells)
67 nM0.44 μM1.24 μM2.15 μM
In vitro (25°C) DMSO 60 mg/mL (201.83 mM)
Water 3 mg/mL (10.09 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.64 mL 168.18 mL 336.36 mL
0.5 mM 6.73 mL 33.64 mL 67.27 mL
1 mM 3.36 mL 16.82 mL 33.64 mL
5 mM 0.67 mL 3.36 mL 6.73 mL

*The above data is based on the productmolecular weight 297.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10632
Actions N/A
M. Wt 297.3
Formula C11H15N5O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 121032-29-9
Synonyms 506U78
SMILES COC1=NC(=NC2=C1N=CN2[[email protected]]3[[email protected]]([[email protected]@H]([[email protected]](O3)CO)O)O)N

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