Nepafenac-d5 is a deuterated derivative of Nepafenac, a nonsteroidal anti-inflammatory drug that functions primarily as a topical COX-2 inhibitor with an IC50 of 0.12 μM. This compound exhibits minimal COX-1 inhibition (IC50 = 64.3 μM) and possesses prodrug characteristics, allowing it to rapidly convert to the active metabolite Amfenac in ocular tissues. Nepafenac-d5 is employed in research to investigate its efficacy in reducing inflammation and managing pain following ophthalmic procedures, as well as its potential to inhibit uveal melanoma metastasis in preclinical models.
Nepafenac-d5 is a deuterated derivative of Nepafenac, a nonsteroidal anti-inflammatory drug that functions primarily as a topical COX-2 inhibitor with an IC50 of 0.12 μM. This compound exhibits minimal COX-1 inhibition (IC50 = 64.3 μM) and possesses prodrug characteristics, allowing it to rapidly convert to the active metabolite Amfenac in ocular tissues. Nepafenac-d5 is employed in research to investigate its efficacy in reducing inflammation and managing pain following ophthalmic procedures, as well as its potential to inhibit uveal melanoma metastasis in preclinical models.
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