Nesiritide, a recombinant form of human B-type natriuretic peptide, primarily functions as an agonist of natriuretic peptide receptors (NPRs), specifically NPR-A and NPR-C, with affinity constants of 7.3 pM and 13 pM, respectively. It effectively regulates the activation and inactivation of L-type calcium channels, resulting in significant vasodilatory, diuretic, and natriuretic effects. Nesiritide is utilized in research on cardiovascular diseases, particularly in models of heart failure and vascular remodeling following arterial injury.
Nesiritide, a recombinant form of human B-type natriuretic peptide, primarily functions as an agonist of natriuretic peptide receptors (NPRs), specifically NPR-A and NPR-C, with affinity constants of 7.3 pM and 13 pM, respectively. It effectively regulates the activation and inactivation of L-type calcium channels, resulting in significant vasodilatory, diuretic, and natriuretic effects. Nesiritide is utilized in research on cardiovascular diseases, particularly in models of heart failure and vascular remodeling following arterial injury.
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