NF-56-EJ40 hydrochloride is a selective antagonist of the human SUCNR1 (GPR91) receptor, exhibiting an IC50 of 25 nM and a Ki of 33 nM. This compound demonstrates minimal activity against rat SUCNR1 while maintaining high affinity for humanized rat SUCNR1, evidenced by a Ki value of 17.4 nM. NF-56-EJ40 hydrochloride is suitable for research applications investigating the role of SUCNR1 in metabolic and cardiovascular diseases.
NF-56-EJ40 hydrochloride is a selective antagonist of the human SUCNR1 (GPR91) receptor, exhibiting an IC50 of 25 nM and a Ki of 33 nM. This compound demonstrates minimal activity against rat SUCNR1 while maintaining high affinity for humanized rat SUCNR1, evidenced by a Ki value of 17.4 nM. NF-56-EJ40 hydrochloride is suitable for research applications investigating the role of SUCNR1 in metabolic and cardiovascular diseases.
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