NF110 is a P2X3 receptor antagonist with a Ki of 36 nM, demonstrating selectivity as it is inactive toward stably expressed P2Y receptors (IC50s > 10 µM). It effectively inhibits alpha, beta-methylene-ATP-induced currents in rat dorsal root ganglia neurons, with an IC50 value of 527 nM. This compound is valuable for researching pain pathways and receptor signaling in nociceptive responses.
NF110 is a P2X3 receptor antagonist with a Ki of 36 nM, demonstrating selectivity as it is inactive toward stably expressed P2Y receptors (IC50s > 10 µM). It effectively inhibits alpha, beta-methylene-ATP-induced currents in rat dorsal root ganglia neurons, with an IC50 value of 527 nM. This compound is valuable for researching pain pathways and receptor signaling in nociceptive responses.
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