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NG25, a TAK1 inhibitor, inhibited the activation of IKK by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells.
| In vitro | DMSO | 85 mg/mL (158.11 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL (3.72 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.6 mL | 93.01 mL | 186.02 mL |
| 0.5 mM | 3.72 mL | 18.6 mL | 37.2 mL |
| 1 mM | 1.86 mL | 9.3 mL | 18.6 mL |
| 5 mM | 0.37 mL | 1.86 mL | 3.72 mL |
*The above data is based on the productmolecular weight 537.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15185 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1315355-93-1 |
| Formula | C29H30F3N5O2 |
| M. Wt | 537.58 |
| Purity | >98% |
| Synonyms | NG 25, NG-25 |
| SMILES | CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=C5C=CNC5=NC=C4)C(F)(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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