MAP4K

GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM.

NG25, a TAK1 inhibitor, inhibited the activation of IKK by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells.

PF-06260933 is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM.

DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96).

NCB-0846 is an orally available TNIK inhibitor with an IC50 of 21?nM.