NH2-PEG1-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker designed for efficient payload delivery. This reagent features a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group, enabling versatile coupling reactions with carboxylic acids, ketones, and aldehydes. The Val-Cit dipeptide undergoes proteolytic cleavage within cells, facilitating the release of drug payloads through an elimination mechanism associated with the PAB structure. This compound is ideal for ADC development and other related bioconjugation applications.
NH2-PEG1-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker designed for efficient payload delivery. This reagent features a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group, enabling versatile coupling reactions with carboxylic acids, ketones, and aldehydes. The Val-Cit dipeptide undergoes proteolytic cleavage within cells, facilitating the release of drug payloads through an elimination mechanism associated with the PAB structure. This compound is ideal for ADC development and other related bioconjugation applications.
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