NH2-PEG4-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker designed for targeted delivery of therapeutic payloads. Its structure includes a primary amine for versatile coupling reactions, a hydrophilic PEG spacer, and a Val-Cit dipeptide that is readily cleaved by cellular proteases, facilitating the release of the drug inside target cells. The PAB moiety enables efficient attachment of reactive groups, enhancing conjugation with drug payloads. This linker is valuable in research applications involving ADC development and optimization, enabling precise targeting in cancer therapy.
NH2-PEG4-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker designed for targeted delivery of therapeutic payloads. Its structure includes a primary amine for versatile coupling reactions, a hydrophilic PEG spacer, and a Val-Cit dipeptide that is readily cleaved by cellular proteases, facilitating the release of the drug inside target cells. The PAB moiety enables efficient attachment of reactive groups, enhancing conjugation with drug payloads. This linker is valuable in research applications involving ADC development and optimization, enabling precise targeting in cancer therapy.
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