NH2-PEG6-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker that incorporates a primary amine, a PEG spacer, a Val-Cit dipeptide, and a PAB group. This design facilitates the attachment of reactive groups, enabling the conjugation of drug payloads through the benzylic alcohol on the PAB moiety. The primary amine allows for versatile reactions, including coupling with carboxylic acids and reductive aminations. Within cells, the Val-Cit dipeptide is cleaved by proteases, promoting efficient drug release via the elimination mechanism inherent to the PAB structure, thus enhancing therapeutic efficacy in targeted delivery applications.
NH2-PEG6-Val-Cit-PAB-OH is a cleavable antibody-drug conjugate (ADC) linker that incorporates a primary amine, a PEG spacer, a Val-Cit dipeptide, and a PAB group. This design facilitates the attachment of reactive groups, enabling the conjugation of drug payloads through the benzylic alcohol on the PAB moiety. The primary amine allows for versatile reactions, including coupling with carboxylic acids and reductive aminations. Within cells, the Val-Cit dipeptide is cleaved by proteases, promoting efficient drug release via the elimination mechanism inherent to the PAB structure, thus enhancing therapeutic efficacy in targeted delivery applications.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
