(+)-Niguldipine hydrochloride is a calcium channel antagonist that effectively induces vasodilation by inhibiting calcium influx through cell membranes. This compound demonstrates significant biological activity by antagonizing U-46619-induced coronary vasoconstriction in guinea pig Langendorff heart preparations, with a pID50 value of 11.37. Additionally, it binds to calcium channels in guinea pig skeletal muscle membranes with a Ki of 9.75 and exhibits blood pressure-lowering effects in spontaneously hypertensive rats, with a pED30 of 7.1. (+)-Niguldipine hydrochloride is utilized in research related to cardiovascular diseases, including hypertension, angina pectoris, and arrhythmias.
(+)-Niguldipine hydrochloride is a calcium channel antagonist that effectively induces vasodilation by inhibiting calcium influx through cell membranes. This compound demonstrates significant biological activity by antagonizing U-46619-induced coronary vasoconstriction in guinea pig Langendorff heart preparations, with a pID50 value of 11.37. Additionally, it binds to calcium channels in guinea pig skeletal muscle membranes with a Ki of 9.75 and exhibits blood pressure-lowering effects in spontaneously hypertensive rats, with a pED30 of 7.1. (+)-Niguldipine hydrochloride is utilized in research related to cardiovascular diseases, including hypertension, angina pectoris, and arrhythmias.
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