NMK-TD-100 is a microtubule modulator that binds to tubulin, effectively inhibiting tubulin polymerization with an IC50 of 17.5 µM. This compound disrupts mitosis and leads to a decrease in mitochondrial membrane potential (MMP). Additionally, NMK-TD-100 demonstrates significant anti-proliferative activity against HeLa cells, with an IC50 of 1.42 µM, causing cell cycle arrest at the G2/M phase and inducing apoptosis. Its applications include studying microtubule dynamics and exploring potential cancer therapies.
NMK-TD-100 is a microtubule modulator that binds to tubulin, effectively inhibiting tubulin polymerization with an IC50 of 17.5 µM. This compound disrupts mitosis and leads to a decrease in mitochondrial membrane potential (MMP). Additionally, NMK-TD-100 demonstrates significant anti-proliferative activity against HeLa cells, with an IC50 of 1.42 µM, causing cell cycle arrest at the G2/M phase and inducing apoptosis. Its applications include studying microtubule dynamics and exploring potential cancer therapies.
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