NMS-873

Catalog No.: A12377

p97 inhibitor

NMS-873

NMS-873 Chemical Structure

CAS NO. 1418013-75-8

NMS-873 is a potent and specific small molecule allosteric inhibitor of the ATPase VCP/p97 (IC50 ~0.03 uM), identified by a high-throughput screening.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
25 mg
$250.00
50 mg
$450.00
10mM * 1mL in DMSO
$75.00
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  • Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7

Biological Activity

NMS-873 is a potent and specific small molecule allosteric inhibitor of the ATPase VCP/p97 (IC50 ~0.03 uM), identified by a high-throughput screening.
Targets
p97
30 nM
In vitro DMSO 98 mg/mL (188.22 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.21 mL 96.03 mL 192.06 mL
0.5 mM 3.84 mL 19.21 mL 38.41 mL
1 mM 1.92 mL 9.6 mL 19.21 mL
5 mM 0.38 mL 1.92 mL 3.84 mL

*The above data is based on the productmolecular weight 520.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12377
Actions Inhibitor
CAS No. 1418013-75-8
Formula C27H28N4O3S2
M. Wt 520.67
Purity >98%
Synonyms NMS873, NMS 873
SMILES CC1=C(C=CC(=C1)OCC2=NN=C(N2C3=CN=CC=C3)SC4CCCC4)C5=CC=C(C=C5)S(=O)(=O)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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