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$0.00 - Yool Lee, .et al. Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle, Sci Adv, 2021, 7
Biological Activity
NMS-873 is a potent and specific small molecule allosteric inhibitor of the ATPase VCP/p97 (IC50 ~0.03 uM), identified by a high-throughput screening.
Targets
| p97 | ||||
| 30 nM |
| In vitro | DMSO | 98 mg/mL (188.22 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.21 mL | 96.03 mL | 192.06 mL |
| 0.5 mM | 3.84 mL | 19.21 mL | 38.41 mL |
| 1 mM | 1.92 mL | 9.6 mL | 19.21 mL |
| 5 mM | 0.38 mL | 1.92 mL | 3.84 mL |
*The above data is based on the productmolecular weight 520.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12377 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1418013-75-8 |
| Formula | C27H28N4O3S2 |
| M. Wt | 520.67 |
| Purity | >98% |
| Synonyms | NMS873, NMS 873 |
| SMILES | CC1=C(C=CC(=C1)OCC2=NN=C(N2C3=CN=CC=C3)SC4CCCC4)C5=CC=C(C=C5)S(=O)(=O)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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