NPFF1-R antagonist 1 is a potent antagonist of the neuropeptide FF (NPFF) receptor, specifically targeting the NPFF1-R subtype. This compound, a piperidine analogue, demonstrates a selective blockade with a Ki of 211 nM for NPFF1-R and 3270 nM for NPFF2-R, indicating a remarkable 15-fold selectivity. It is suitable for research applications exploring neuropeptide signaling pathways and potential neurological disorders linked to NPFF receptor activity.
NPFF1-R antagonist 1 is a potent antagonist of the neuropeptide FF (NPFF) receptor, specifically targeting the NPFF1-R subtype. This compound, a piperidine analogue, demonstrates a selective blockade with a Ki of 211 nM for NPFF1-R and 3270 nM for NPFF2-R, indicating a remarkable 15-fold selectivity. It is suitable for research applications exploring neuropeptide signaling pathways and potential neurological disorders linked to NPFF receptor activity.
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