NS004 is a potent activator of large-conductance calcium-activated potassium (BK) channels, enhancing Iberiotoxin and Tetraethylammonium-sensitive whole-cell efflux currents. This compound significantly boosts the activity of individual BK channels in GH3 cells and rat brain channels integrated into planar lipid bilayers. The observed effects include increased channel mean open time, reduced intermittent time, and enhanced voltage and calcium sensitivity, making NS004 valuable for research on potassium channel modulation and related physiological processes.
NS004 is a potent activator of large-conductance calcium-activated potassium (BK) channels, enhancing Iberiotoxin and Tetraethylammonium-sensitive whole-cell efflux currents. This compound significantly boosts the activity of individual BK channels in GH3 cells and rat brain channels integrated into planar lipid bilayers. The observed effects include increased channel mean open time, reduced intermittent time, and enhanced voltage and calcium sensitivity, making NS004 valuable for research on potassium channel modulation and related physiological processes.
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