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$0.00 - Kittaka M, .et al. Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts, J Bone Miner Res, 2018, Jan;33(1):167-181 PMID: 28914985
Biological Activity
NSC-405020 is a membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L).
Targets
| MT1-MMP | ||||
| In vitro (25°C) | DMSO | 48 mg/mL (184.5 mM) | |
| Water | Insoluble | ||
| Ethanol | 48 mg/mL (184.5 mM) | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 38.44 mL | 192.19 mL | 384.38 mL |
| 0.5 mM | 7.69 mL | 38.44 mL | 76.88 mL |
| 1 mM | 3.84 mL | 19.22 mL | 38.44 mL |
| 5 mM | 0.77 mL | 3.84 mL | 7.69 mL |
*The above data is based on the productmolecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13072 |
|---|---|
| Actions | Inhibitor |
| CAS No. | CAS: 7497-07-6 |
| Formula | C12H15Cl2NO |
| M. Wt | 260.16 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | NSC405020, NSC-405020 |
| SMILES | CCCC(C)NC(=O)C1=CC(=C(C=C1)Cl)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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