NSC 405020

Catalog No.: A13072

MT1-MMP inhibitor

NSC 405020

NSC 405020 Chemical Structure

CAS NO. CAS: 7497-07-6

NSC-405020 is a membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L).

Availability: In stock

Package Price Qty
10 mg
$55.00
25 mg
$110.00
50 mg
$210.00
100 mg
$360.00
10mM * 1mL in DMSO
$75.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Kittaka M, .et al. Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts, J Bone Miner Res, 2018, Jan;33(1):167-181 PMID: 28914985

Biological Activity

NSC-405020 is a membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L).
Targets
MT1-MMP
In vitro (25°C) DMSO 52 mg/mL (199.87 mM)
Water <1 mg/mL (<1 mM)
Ethanol 52 mg/mL (199.87 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.44 mL 192.19 mL 384.38 mL
0.5 mM 7.69 mL 38.44 mL 76.88 mL
1 mM 3.84 mL 19.22 mL 38.44 mL
5 mM 0.77 mL 3.84 mL 7.69 mL

*The above data is based on the productmolecular weight 260.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13072
Actions Inhibitor
M. Wt 260.16
Formula C12H15Cl2NO
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. CAS: 7497-07-6
Synonyms NSC405020, NSC-405020
SMILES CCCC(C)NC(=O)C1=CC(=C(C=C1)Cl)Cl

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