NVP-ABE171 is a potent, orally active inhibitor of phosphodiesterase 4 (PDE4) that exhibits selective IC50 values of 1.5 nM for PDE4D, 34 nM for PDE4B, 602 nM for PDE4A, and 1230 nM for PDE4C. This compound significantly increases cAMP levels in response to isoproterenol, while also inhibiting eosinophil oxidative bursts and inflammatory cytokine release from T cells and monocytes. NVP-ABE171 demonstrates strong anti-inflammatory effects in preclinical models of asthma and pulmonary inflammation, making it a valuable tool for studying asthma and chronic obstructive pulmonary disease.
NVP-ABE171 is a potent, orally active inhibitor of phosphodiesterase 4 (PDE4) that exhibits selective IC50 values of 1.5 nM for PDE4D, 34 nM for PDE4B, 602 nM for PDE4A, and 1230 nM for PDE4C. This compound significantly increases cAMP levels in response to isoproterenol, while also inhibiting eosinophil oxidative bursts and inflammatory cytokine release from T cells and monocytes. NVP-ABE171 demonstrates strong anti-inflammatory effects in preclinical models of asthma and pulmonary inflammation, making it a valuable tool for studying asthma and chronic obstructive pulmonary disease.
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