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Biological Activity
NVP-BAG956 acts as a potent, reversible, and ATP-competitive PI 3-K/PDK1 dual kinase inhibitor, displaying much reduced potency against VEGFR1 (IC50 = 2.56 uM) and little or no activity toward a panel of 15 other kinases (IC50 >10 uM).
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.39 mL | 116.96 mL | 233.92 mL |
0.5 mM | 4.68 mL | 23.39 mL | 46.78 mL |
1 mM | 2.34 mL | 11.7 mL | 23.39 mL |
5 mM | 0.47 mL | 2.34 mL | 4.68 mL |
*The above data is based on the productmolecular weight 427.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11511 |
---|---|
Actions | Inhibitor |
CAS No. | 853910-02-8 |
Formula | C28H21N5 |
M. Wt | 427.5 |
Purity | >98% |
Synonyms | NVP-BAG 956 |
SMILES | CC1=NC2=CN=C3C=CC(=CC3=C2N1C4=CC=C(C=C4)C(C)(C)C#N)C#CC5=CN=CC=C5 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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