NXE0041178 is a potent full agonist of the GPR52 receptor, exhibiting a pEC50 of 7.5 for human GPR52 and an EC50 of 27.5 nM for rat GPR52. This compound demonstrates an ability to penetrate the blood-brain barrier and shows minimal inhibition of hERG, hNaV1.5, and cytochrome P450 isoforms. Notably, NXE0041178 effectively reduces d-amphetamine-induced hyperactivity in rat models, making it a valuable tool for research related to neurological disorders.
NXE0041178 is a potent full agonist of the GPR52 receptor, exhibiting a pEC50 of 7.5 for human GPR52 and an EC50 of 27.5 nM for rat GPR52. This compound demonstrates an ability to penetrate the blood-brain barrier and shows minimal inhibition of hERG, hNaV1.5, and cytochrome P450 isoforms. Notably, NXE0041178 effectively reduces d-amphetamine-induced hyperactivity in rat models, making it a valuable tool for research related to neurological disorders.
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