ω-Grammotoxin SIA

Catalog No.: A66201
Calcium Channels Inhibitor
ω-Grammotoxin SIA is a selective inhibitor of P/Q and N-type voltage-gated calcium channels, derived from spider venom. This protein toxin is instrumental in studying calcium's role in neuronal and cardiovascular signaling pathways. Its unique mechanism allows researchers to explore its potential applications in understanding and treating various neurological and cardiovascular diseases.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Descriptionω-Grammotoxin SIA is a selective inhibitor of P/Q and N-type voltage-gated calcium channels, derived from spider venom. This protein toxin is instrumental in studying calcium's role in neuronal and cardiovascular signaling pathways. Its unique mechanism allows researchers to explore its potential applications in understanding and treating various neurological and cardiovascular diseases.
Product Information
Catalog NumA66201
FormulaC177H263N53O49S6
Molecular Weight4109.70
CAS Number152617-90-8
SequenceAsp-Cys-Val-Arg-Phe-Trp-Gly-Lys-Cys-Ser-Gln-Thr-Ser-Asp-Cys-Cys-Pro-His-Leu-Ala-Cys-Lys-Ser-Lys-Trp-Pro-Arg-Asn-Ile-Cys-Val-Trp-Asp-Gly-Ser-Val-NH2 (Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys30)
Sequence shorteningDCVRFWGKCSQTSDCCPHLACKSKWPRNICVWDGSV-NH2 (Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys30)
SynonymsGrTx; ω-GsTx SIA
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