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Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 2.28 mL | 11.38 mL | 22.76 mL |
| 0.5 mM | 0.46 mL | 2.28 mL | 4.55 mL |
| 1 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 5 mM | 0.05 mL | 0.23 mL | 0.46 mL |
*The above data is based on the productmolecular weight 4393.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17185 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 4393.07 |
| Formula | C184H284N52O57S8 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | Obtustatin |
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