ODS-2004436

Catalog No.: A28675
EGFR Radiotracer
ODS-2004436 is a small molecule radiotracer that targets the epidermal growth factor receptor (EGFR) for use in positron emission tomography (PET) imaging. This compound exhibits significantly higher uptake in xenograft models of lung cancer harboring EGFR mutations compared to wild-type models, enabling effective differentiation of mutation status. ODS-2004436 is valuable for identifying EGFR-positive tumors and predicting therapeutic responses, particularly in non-small cell lung cancer (NSCLC) research applications.
Grouped product items
Size Stock
5mg
10mg
50mg
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Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionODS-2004436 is a small molecule radiotracer that targets the epidermal growth factor receptor (EGFR) for use in positron emission tomography (PET) imaging. This compound exhibits significantly higher uptake in xenograft models of lung cancer harboring EGFR mutations compared to wild-type models, enabling effective differentiation of mutation status. ODS-2004436 is valuable for identifying EGFR-positive tumors and predicting therapeutic responses, particularly in non-small cell lung cancer (NSCLC) research applications.
Product Information
Catalog NumA28675
FormulaC26H29Cl18FN5O4
Molecular Weight528.99
CAS Number2130982-18-0
SMILESClC1=CC(NC2=NC=NC3=CC(OCC[18F])=C(OCCCNC([C@@H](C(C)C)N4)=O)C=C23)=C(CC4=O)C=C1
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