OGT-IN-1 is a selective inhibitor of O-GlcNAc transferase (OGT), with IC50 values of 27 μM for soluble OGT (sOGT) and 10 μM for nuclear OGT (ncOGT). This compound plays a crucial role in regulating protein O-GlcNAcylation, thereby influencing various cellular processes such as signal transduction and gene expression. OGT-IN-1 is valuable for research applications focused on studying OGT-related metabolic disorders, cancer biology, and neurodegenerative diseases.
OGT-IN-1 is a selective inhibitor of O-GlcNAc transferase (OGT), with IC50 values of 27 μM for soluble OGT (sOGT) and 10 μM for nuclear OGT (ncOGT). This compound plays a crucial role in regulating protein O-GlcNAcylation, thereby influencing various cellular processes such as signal transduction and gene expression. OGT-IN-1 is valuable for research applications focused on studying OGT-related metabolic disorders, cancer biology, and neurodegenerative diseases.
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