OGT

OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells.

UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (OGT).

OSMI-1 is a potent cell-permeable inhibitor of O-GlcNAc transferase (OGT), with an IC50 value of 2.7 μM. This compound effectively decreases protein O-linked N-acetylglucosamine (O-GlcNAcylation) levels in various mammalian cell lines while maintaining the integrity of cell surface N- and O-linked glycans. OSMI-1 serves as a valuable tool for studying the regulatory roles of O-GlcNAcylation in cellular processes and diseases.

ST045849 is a small-molecule inhibitor targeting O-GlcNAc transferase (OGT) with an IC50 of 30 μM against the soluble form of OGT (sOGT) and 53 μM against the nuclear/cytoplasmic form (ncOGT). This compound is valuable for studying the role of OGT in metabolism-related diseases, providing insights into regulatory mechanisms involving O-GlcNAcylation. Its application aids in understanding the biological implications of OGT inhibition in various pathological conditions.

OSMI-2 is a selective inhibitor of O-linked N-acetylglucosamine transferase (OGT), designed for cellular permeability. This compound has been shown to enhance the splicing of retained introns in various cell types, making it a valuable tool for studying the regulation of alternative splicing and OGT's role in cellular processes. OSMI-2 is applicable in various research fields, including cancer biology and neurodegenerative disorders, where OGT activity is implicated.

(Rac)-OSMI-1 is a racemic mixture of OSMI-1, a potent inhibitor of O-GlcNAc transferase (OGT) that exhibits an IC50 value of 2.7 μM. This compound effectively inhibits O-linked N-acetylglucosamine (O-GlcNAcylation) in various mammalian cell lines, while not significantly affecting cell surface N- or O-linked glycans. Its application spans diverse studies in cellular signaling and glycosylation modifications, making it a valuable tool for research into OGT-related biological processes.

OSMI-3 is a selective inhibitor of O-linked N-acetylglucosamine transferase (OGT), characterized by its potent and cell-permeable properties. This compound effectively modulates OGT activity, leading to the enhancement of retained intron splicing in cellular contexts. OSMI-3 is valuable in research investigating the role of OGT in cellular processes and its implications in various disease states.

OGT-IN-1 is a selective inhibitor of O-GlcNAc transferase (OGT), with IC50 values of 27 μM for soluble OGT (sOGT) and 10 μM for nuclear OGT (ncOGT). This compound plays a crucial role in regulating protein O-GlcNAcylation, thereby influencing various cellular processes such as signal transduction and gene expression. OGT-IN-1 is valuable for research applications focused on studying OGT-related metabolic disorders, cancer biology, and neurodegenerative diseases.

PG 34 is a selective inhibitor of O-GlcNAc transferase (OGT), exhibiting an IC50 value of 68 μM. This compound targets the OGT enzyme, playing a crucial role in the regulation of O-GlcNAcylation. PG 34 is primarily applied in studies of cellular signaling, metabolic processes, and glycosylation-related research, offering insights into the role of OGT in various biological contexts.

OGT-IN-4 is a potent inhibitor of O-GlcNAc transferase (OGT), displaying a dissociation constant (Kd) of 8 nM. This compound is valuable for investigating the role of OGT in various biological processes and diseases, including metabolic disorders and cancer. Its specificity makes OGT-IN-4 a useful tool for researchers studying O-GlcNAcylation and its impact on cellular signaling pathways.

BZX2 is an irreversible covalent inhibitor of O-GlcNAc transferase (OGT), demonstrating an IC50 of less than 10 µM. This compound is cell-permeable, allowing for effective intracellular delivery, though it may exhibit multiple off-target effects. BZX2 is primarily utilized in research applications focused on OGT-related signaling pathways and O-GlcNAcylation processes in various biological contexts.

Ac4-5SGlcNAc is a pro-inhibitor targeting carbohydrate-based glycosyltransferases, particularly OGTs. This compound effectively inhibits O-GlcNAc acylation, resulting in the modulation of neural induction processes in human embryonic stem cells and a reduction in the invasive characteristics of breast cancer cells. Additionally, Ac4-5SGlcNAc demonstrates broader activity against various carbohydrate-processing enzymes, making it a valuable tool for biochemical assays in glycosylation research.