ON-01910 (rigosertib)

Catalog No.: A10673

PLK Inhibitor

ON-01910 (rigosertib)

ON-01910 (rigosertib) Chemical Structure

CAS NO. 1225497-78-8

ON-01910 is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$100.00
50 mg
$280.00
100 mg
$480.00
10mM * 1mL in DMSO
$116.00
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Biological Activity

ON-01910 is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress.
Targets
PLK1 (Cell-free assay)
9 nM
In vitro (25°C) DMSO 95 mg/mL (200.64 mM)
Water 95 mg/mL (200.64 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.12 mL 105.6 mL 211.19 mL
0.5 mM 4.22 mL 21.12 mL 42.24 mL
1 mM 2.11 mL 10.56 mL 21.12 mL
5 mM 0.42 mL 2.11 mL 4.22 mL

*The above data is based on the productmolecular weight 473.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10673
Actions Inhibitor
M. Wt 473.5
Formula C21H24NNaO8S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1225497-78-8
Synonyms ON01910, ON 01910.Na, Estybon, Novonex, Rigosertib
SMILES COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]

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