ONO-2920632 is an orally active TREK activator that effectively penetrates the central nervous system, exhibiting EC50 values of 0.3 µM for TREK-1 and 2.8 µM for TREK-2. This compound demonstrates significant selectivity for TREK channels over other K2P channels, showing more than 91-fold selectivity versus TASK1, TASK2, TASK3, TRAAK, and TWIK2, as well as 31-fold selectivity for TRESK. ONO-2920632 is recognized for its analgesic properties and is suitable for research applications in pain management, migraine, and various neurological disorders.
ONO-2920632 is an orally active TREK activator that effectively penetrates the central nervous system, exhibiting EC50 values of 0.3 µM for TREK-1 and 2.8 µM for TREK-2. This compound demonstrates significant selectivity for TREK channels over other K2P channels, showing more than 91-fold selectivity versus TASK1, TASK2, TASK3, TRAAK, and TWIK2, as well as 31-fold selectivity for TRESK. ONO-2920632 is recognized for its analgesic properties and is suitable for research applications in pain management, migraine, and various neurological disorders.
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