OPC-33540 is a highly selective and competitive inhibitor of phosphodiesterase 3 (PDE3), exhibiting IC50 values of 0.32 nM for PDE3A and 1.5 nM for PDE3B. This compound demonstrates significantly reduced activity against other phosphodiesterases, with IC50 values ranging from 42.9 μM to 100.8 μM for PDE1, PDE2, PDE4, PDE5, and PDE7. OPC-33540 effectively increases cAMP levels in platelets and inhibits thrombin-induced platelet aggregation, making it a valuable tool for antithrombotic research applications.
OPC-33540 is a highly selective and competitive inhibitor of phosphodiesterase 3 (PDE3), exhibiting IC50 values of 0.32 nM for PDE3A and 1.5 nM for PDE3B. This compound demonstrates significantly reduced activity against other phosphodiesterases, with IC50 values ranging from 42.9 μM to 100.8 μM for PDE1, PDE2, PDE4, PDE5, and PDE7. OPC-33540 effectively increases cAMP levels in platelets and inhibits thrombin-induced platelet aggregation, making it a valuable tool for antithrombotic research applications.
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