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Org20599

Catalog No.: A66802
GABAA agonist
Org20599 is a positive allosteric modulator and, at elevated concentrations, a direct agonist of the GABAA receptor, exhibiting an EC50 of 1.1 μM. This compound enhances GABAA receptor activity, contributing to the modulation of inhibitory neurotransmission. Org20599 is utilized in research exploring the effects of GABAergic signaling on various neurological conditions and for the investigation of anxiolytic and anticonvulsant properties.
Org20599 156685-94-8 GABAA agonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionOrg20599 is a positive allosteric modulator and, at elevated concentrations, a direct agonist of the GABAA receptor, exhibiting an EC50 of 1.1 μM. This compound enhances GABAA receptor activity, contributing to the modulation of inhibitory neurotransmission. Org20599 is utilized in research exploring the effects of GABAergic signaling on various neurological conditions and for the investigation of anxiolytic and anticonvulsant properties.
Product Information
Catalog NumA66802
FormulaC25H40ClNO3
Molecular Weight438.04
CAS Number156685-94-8
SMILESC[C@@]12[C@@H](C(CCl)=O)CC[C@@]1([H])[C@]3([H])CC[C@@]4([H])C[C@H](O)[C@@H](N5CCOCC5)C[C@]4(C)[C@@]3([H])CC2
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Neuronal Signaling > GABA Receptors