OSK-1 is a potent blocker of voltage-gated potassium (Kv) channels, specifically exhibiting IC50 values of 0.6 nM, 5.4 nM, and 0.014 nM for Kv1.1, Kv1.2, and Kv1.3, respectively. Additionally, OSK-1 demonstrates moderate activity against the Ca2+-activated KCa3.1 channel, with an IC50 of 225 nM. As a member of the α-KTx3 toxin family, OSK-1 serves as an immunosuppressive agent and is valuable in research exploring potassium channel modulation and its effects on cellular signaling pathways.
OSK-1 is a potent blocker of voltage-gated potassium (Kv) channels, specifically exhibiting IC50 values of 0.6 nM, 5.4 nM, and 0.014 nM for Kv1.1, Kv1.2, and Kv1.3, respectively. Additionally, OSK-1 demonstrates moderate activity against the Ca2+-activated KCa3.1 channel, with an IC50 of 225 nM. As a member of the α-KTx3 toxin family, OSK-1 serves as an immunosuppressive agent and is valuable in research exploring potassium channel modulation and its effects on cellular signaling pathways.
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