OTS193320 is an imidazo[1,2-a]pyridine compound that acts as a selective inhibitor of the SUV39H2 methyltransferase. It effectively reduces global histone H3 lysine 9 tri-methylation levels in breast cancer cells, leading to apoptosis. Additionally, the combination of OTS193320 with Doxorubicin has been shown to significantly decrease γ-H2AX levels and enhance the reduction in cancer cell viability compared to the use of either compound alone. This makes OTS193320 a valuable tool for understanding the role of histone modifications in cancer therapy.
OTS193320 is an imidazo[1,2-a]pyridine compound that acts as a selective inhibitor of the SUV39H2 methyltransferase. It effectively reduces global histone H3 lysine 9 tri-methylation levels in breast cancer cells, leading to apoptosis. Additionally, the combination of OTS193320 with Doxorubicin has been shown to significantly decrease γ-H2AX levels and enhance the reduction in cancer cell viability compared to the use of either compound alone. This makes OTS193320 a valuable tool for understanding the role of histone modifications in cancer therapy.
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