Fig. 1 · Structure
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p,p'-DDD-d8
Stable Isotope
p,p'-DDD-d8 is a deuterium-labeled derivative of p,p'-DDD, an organochlorine insecticide and significant metabolite of p,p'-DDT. This compound acts as an agonist for estrogen receptors α (ERα) and β (ERβ), influencing cellular pathways linked to DNA damage, apoptosis, and necrosis in peripheral blood. Additionally, p,p'-DDD has been shown to promote cell proliferation in SKBR3 cells and activate the AP-1 transcription factor. Its effects on sleep patterns, particularly reducing sleep times induced by barbiturates and steroids in rat models, highlight its potential relevance in pharmacological studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 93952-20-6 |
| Applications | Stable Isotope |
| Formula | C14H2D8Cl4 |
| Molecular Weight | 328.09 |
| Synonyms | 4,4'-DDD-d8; p,p'-Dichlorodiphenyl dichloroethane-d8 |
| SMILES | ClC(Cl)C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)C2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.