P2X3 antagonist 38 is a potent oral antagonist of the P2X3 receptor, demonstrating IC50 values of 0.132 µM for human P2X3, 0.165 µM for rat P2X3, and 0.421 µM for guinea pig P2X3. This compound is valuable in studies focused on pain modulation and respiratory disorders, positioning it as a significant tool for researching the role of P2X3 in various biological processes. Its high selectivity and efficacy make it suitable for in vivo applications in pharmacological investigations.
P2X3 antagonist 38 is a potent oral antagonist of the P2X3 receptor, demonstrating IC50 values of 0.132 µM for human P2X3, 0.165 µM for rat P2X3, and 0.421 µM for guinea pig P2X3. This compound is valuable in studies focused on pain modulation and respiratory disorders, positioning it as a significant tool for researching the role of P2X3 in various biological processes. Its high selectivity and efficacy make it suitable for in vivo applications in pharmacological investigations.
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