P2X7 receptor antagonist-3

Catalog No.: A67929
P2X7 Receptor Antagonist
P2X7 receptor antagonist-3 is a highly potent antagonist of the P2X7 receptor, demonstrating IC50 values of 4.2 nM in human cells and 6.8 nM in rat models. This compound inhibits the activation of the P2X7 receptor, which is involved in inflammatory responses and various signaling pathways. It is suitable for research applications focused on pain, neuroinflammation, and autoimmune diseases, enabling the exploration of therapeutic strategies targeting P2X7 receptor-mediated mechanisms.
Grouped product items
Size Price Stock Qty
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
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Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionP2X7 receptor antagonist-3 is a highly potent antagonist of the P2X7 receptor, demonstrating IC50 values of 4.2 nM in human cells and 6.8 nM in rat models. This compound inhibits the activation of the P2X7 receptor, which is involved in inflammatory responses and various signaling pathways. It is suitable for research applications focused on pain, neuroinflammation, and autoimmune diseases, enabling the exploration of therapeutic strategies targeting P2X7 receptor-mediated mechanisms.
Product Information
Catalog NumA67929
FormulaC17H12ClF3N6O
Molecular Weight408.76
CAS Number1627900-92-8
SMILESO=C(N1CC2=C(CC1)N(C3=NC=CC=N3)N=N2)C4=CC=CC(C(F)(F)F)=C4Cl
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