p38 MAPK-IN-7

Catalog No.: A40852
p38 MAP Kinase Inhibitor
p38 MAPK-IN-7 is a selective inhibitor of p38 MAP kinase, exhibiting an IC50 value of 170 nM. This compound demonstrates potent inhibition of p38 MAPK activity, making it a valuable tool for investigating the role of this kinase in various inflammatory diseases, including rheumatoid arthritis and septic shock. Its oral bioavailability enhances its potential for in vivo studies aimed at understanding the therapeutic implications of p38 MAPK modulation.
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5mg
10mg
50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Descriptionp38 MAPK-IN-7 is a selective inhibitor of p38 MAP kinase, exhibiting an IC50 value of 170 nM. This compound demonstrates potent inhibition of p38 MAPK activity, making it a valuable tool for investigating the role of this kinase in various inflammatory diseases, including rheumatoid arthritis and septic shock. Its oral bioavailability enhances its potential for in vivo studies aimed at understanding the therapeutic implications of p38 MAPK modulation.
Product Information
Catalog NumA40852
FormulaC16H16FN5
Molecular Weight297.33
CAS Number165806-50-8
SMILESFC1=CC=C(C2=C(C3=CC=NC(N)=N3)N(C(C)C)C=N2)C=C1
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