p53 (17-26) is a peptide derived from the MDM2 binding domain of the tumor suppressor p53, with a binding affinity (Kd) of 50 nM for MDM2. This peptide demonstrates significant biological activity by inducing necrosis in cancer cells through disruption of cellular integrity and nuclear membrane damage. Research applications for p53 (17-26) include studies focused on pancreatic cancer and the development of therapeutic strategies targeting MDM2-mediated pathways.
p53 (17-26) is a peptide derived from the MDM2 binding domain of the tumor suppressor p53, with a binding affinity (Kd) of 50 nM for MDM2. This peptide demonstrates significant biological activity by inducing necrosis in cancer cells through disruption of cellular integrity and nuclear membrane damage. Research applications for p53 (17-26) include studies focused on pancreatic cancer and the development of therapeutic strategies targeting MDM2-mediated pathways.
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