Pacritinib (SB1518)

Catalog No.: A12694

JAK2/FLT3 inhibitor

Pacritinib (SB1518)

Pacritinib (SB1518) Chemical Structure

CAS NO. 937272-79-2

Pacritinib, also known as SB1518, is an orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis.

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5 mg

Regular Price: $70.00

Special Price $56.00

10 mg

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Special Price $80.00

25 mg

Regular Price: $180.00

Special Price $144.00

50 mg

Regular Price: $260.00

Special Price $208.00

10mM * 1mL in DMSO

Regular Price: $248.00

Special Price $198.40

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Daniel Doheny, .et al. Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis, Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154

Biological Activity

Pacritinib, also known as SB1518, is an orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis.
In vitro DMSO Warmed: 10 mg/mL (21.15 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.16 mL 105.8 mL 211.6 mL
0.5 mM 4.23 mL 21.16 mL 42.32 mL
1 mM 2.12 mL 10.58 mL 21.16 mL
5 mM 0.42 mL 2.12 mL 4.23 mL

*The above data is based on the productmolecular weight 472.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12694
Actions Inhibitor
CAS No. 937272-79-2
Formula C28H32N4O3
M. Wt 472.58
Solubility DMSO
Purity >98%
Synonyms SB-1518; SB 1518
SMILES C1CCN(C1)CCOC2=C3COC/C=C/COCC4=CC=CC(=C4)C5=NC(=NC=C5)NC(=C3)C=C2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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