Palmatine is a selective, irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1), exhibiting IC50 values of 3 μM against HEK 293-hIDO-1 and 157 μM against rhIDO-1. Additionally, Palmatine effectively inhibits the West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. This compound demonstrates diverse biological activities including anti-cancer, anti-oxidation, anti-inflammatory, neuroprotective, antibacterial, and antiviral effects, making it a valuable tool for research in cancer biology, inflammation, and infectious diseases.
Palmatine is a selective, irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1), exhibiting IC50 values of 3 μM against HEK 293-hIDO-1 and 157 μM against rhIDO-1. Additionally, Palmatine effectively inhibits the West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. This compound demonstrates diverse biological activities including anti-cancer, anti-oxidation, anti-inflammatory, neuroprotective, antibacterial, and antiviral effects, making it a valuable tool for research in cancer biology, inflammation, and infectious diseases.
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