Pan-Raf/RTK inhibitor 1 (compound I-16) is a highly selective pan-Raf inhibitor that targets the Raf kinases with IC50 values of 3.49 nM for BRafV600E, 8.86 nM for ARaf, 5.78 nM for BRafWT, and 1.65 nM for CRaf. This compound exhibits significant antiproliferative effects across a range of cancer cell lines, making it a valuable tool for cancer research. Its ability to inhibit multiple Raf isoforms facilitates studies investigating the role of the Raf signaling pathway in tumorigenesis and therapeutic resistance.
Pan-Raf/RTK inhibitor 1 (compound I-16) is a highly selective pan-Raf inhibitor that targets the Raf kinases with IC50 values of 3.49 nM for BRafV600E, 8.86 nM for ARaf, 5.78 nM for BRafWT, and 1.65 nM for CRaf. This compound exhibits significant antiproliferative effects across a range of cancer cell lines, making it a valuable tool for cancer research. Its ability to inhibit multiple Raf isoforms facilitates studies investigating the role of the Raf signaling pathway in tumorigenesis and therapeutic resistance.
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