Pazopanib-d3 hydrochloride is a deuterated form of Pazopanib, serving as a stable isotope labeled compound. This multi-targeted inhibitor effectively modulates several receptor tyrosine kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms, with respective IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM. Its unique isotopic signature allows for precise tracking and analysis in biological studies, making it suitable for pharmacokinetic research and metabolic studies in oncology and related fields.
Pazopanib-d3 hydrochloride is a deuterated form of Pazopanib, serving as a stable isotope labeled compound. This multi-targeted inhibitor effectively modulates several receptor tyrosine kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms, with respective IC50 values of 10, 30, 47, 84, 74, 140, and 146 nM. Its unique isotopic signature allows for precise tracking and analysis in biological studies, making it suitable for pharmacokinetic research and metabolic studies in oncology and related fields.
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