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PD 0332991 HCl (Palbociclib)

PD 0332991 HCl (Palbociclib)

Name: PD 0332991 HCl (Palbociclib)
Brand: Adooq Bioscience
SKU: A10701
Rating: 100 (2 reviews)

Catalog No.: A10701

CDK 4/6 inhibitor

Product Citations (2)

PD 0332991 HCl (Palbociclib) Chemical Structure

CAS NO. 827022-32-2

PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

Availability: In stock

Package	Price	Qty
5 mg	$50.00
10 mg	$70.00
25 mg	$85.00
50 mg	$100.00
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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Publications Citing Use of Adooq PD 0332991 HCl (Palbociclib)

Cong Li, .et al. AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia., Mol Cancer Ther., 2015, Feb;14(2):375-83. PMID: 25487917
Pirita Pekkonen, .et al. KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo, Cell Cycle., 2014, Dec 1; 13(23): 3670-3684. PMID: 25483078

Biological Activity

PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

Targets

Target	Value
CDK4/CyclinD3	IC50: 9nM
CDK4/CyclinD1	IC50: 11nM
CDK6/CyclinD2	IC50: 15nM
CDK2/CyclinE2	IC50: >10μM
CDK2/CyclinA	IC50: >10μM
CDK1/CyclinB	IC50: >10μM
CDK5/p25	IC50: >10μM
EGFR	IC50: >10μM
FGFR	IC50: >10μM
PDGFR	IC50: >10μM
Insulin Receptor	IC50: >10μM
VEGFR	IC50: >10μM
AMPK	IC50: >10μM
Chk1	IC50: >10μM
CK1	IC50: >10μM
CK2	IC50: >10μM
c-Src	IC50: >10μM
GSK-3β	IC50: >10μM
MAPK2/ERK2	IC50: >10μM
MAPKAPK2	IC50: >10μM
PKB	IC50: >10μM
PKC	IC50: >10μM
PHK	IC50: >10μM
SAPK2a	IC50: >10μM
SAPK3	IC50: >10μM
SAPK4	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	3 mg/mL (6.19 mM)
	Water	30 mg/mL (61.98 mM)
	Ethanol	<1 mg/mL (<1 mM)
In vivo	Saline	20 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.35 mL	111.73 mL	223.46 mL
0.5 mM	4.47 mL	22.35 mL	44.69 mL
1 mM	2.23 mL	11.17 mL	22.35 mL
5 mM	0.45 mL	2.23 mL	4.47 mL

*The above data is based on the productmolecular weight 447.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10701
Actions	Inhibitor
M. Wt	447.5
Formula	C24H29N7O2.HCl
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	827022-32-2
SMILES	CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl