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Publications citing Adooq Products
PD 0332991 HCl (Palbociclib) Citations (2)
- Cong Li,et al. AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia., Mol Cancer Ther., 2015, Feb;14(2):375-83. 25487917
- Pirita Pekkonen,et al. KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo, Cell Cycle., 2014, Dec 1; 13(23): 3670-3684. 25483078
Chemical Information
| Catalog Num | A10701 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 447.5 |
| Formula | C24H29N7O2.HCl |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 827022-32-2 |
| Synonyms | N/A |
| SMILES code | CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl |
| Chemical Name | Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-, monohydrochloride |
Description |
PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Targets |
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| Solubility (25°C) * | In vitro | DMSO | 3 mg/mL (6.19 mM) |
|---|---|---|---|
| Water | 30 mg/mL (61.98 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | Saline | 20 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.35 mL | 111.73 mL | 223.46mL |
| 0.5 mM | 4.47 mL | 22.35 mL | 44.69 mL |
| 1 mM | 2.23 mL | 11.17 mL | 22.35 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.47 mL |
*The above data is based on the productmolecular weight 447.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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