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PD 0332991 HCl (Palbociclib)


CDK 4/6 inhibitor

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Catalog No. A10701

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PD 0332991 HCl 5mg A10701-5

Regular Price: $50.00

Special Price: $45.00

PD 0332991 HCl 10mg A10701-10

Regular Price: $70.00

Special Price: $63.00

PD 0332991 HCl 25mg A10701-25

Regular Price: $85.00

Special Price: $76.50

PD 0332991 HCl 50mg A10701-50

Regular Price: $100.00

Special Price: $90.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

PD 0332991 HCl (Palbociclib)

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Publications citing Adooq Products
PD 0332991 HCl (Palbociclib) Citations (2)
  • Cong Li, .et al. AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia., Mol Cancer Ther., 2015, Feb;14(2):375-83. PMID: 25487917
  • Pirita Pekkonen, .et al. KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo, Cell Cycle., 2014, Dec 1; 13(23): 3670-3684. PMID: 25483078

Chemical Information

Catalog Num A10701
Actions Inhibitor
M. Wt 447.5
Formula C24H29N7O2.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 827022-32-2
Synonyms N/A

Biological Activity

PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.
Target Value
CDK4/CyclinD3IC50: 9nM
CDK4/CyclinD1IC50: 11nM
CDK6/CyclinD2IC50: 15nM
CDK2/CyclinE2IC50: >10μM
CDK2/CyclinAIC50: >10μM
CDK1/CyclinBIC50: >10μM
CDK5/p25IC50: >10μM
EGFRIC50: >10μM
FGFRIC50: >10μM
PDGFRIC50: >10μM
Insulin ReceptorIC50: >10μM
VEGFRIC50: >10μM
AMPKIC50: >10μM
Chk1IC50: >10μM
CK1IC50: >10μM
CK2IC50: >10μM
c-SrcIC50: >10μM
GSK-3βIC50: >10μM
MAPK2/ERK2IC50: >10μM
PKBIC50: >10μM
PKCIC50: >10μM
PHKIC50: >10μM
SAPK2aIC50: >10μM
SAPK3IC50: >10μM
SAPK4IC50: >10μM


Solubility (25°C) * In vitro DMSO 3 mg/mL (6.19 mM)
Water 30 mg/mL (61.98 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.35 mL 111.73 mL 223.46mL
0.5 mM 4.47 mL 22.35 mL 44.69 mL
1 mM 2.23 mL 11.17 mL 22.35 mL
5 mM 0.45 mL 2.23 mL 4.47 mL

*The above data is based on the productmolecular weight 447.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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