PD 0332991 HCl (Palbociclib)

Catalog No.: A10701

CDK 4/6 inhibitor

PD 0332991 HCl (Palbociclib)

PD 0332991 HCl (Palbociclib) Chemical Structure

CAS NO. 827022-32-2

PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

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  • Cong Li, .et al. AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia., Mol Cancer Ther., 2015, Feb;14(2):375-83. PMID: 25487917
  • Pirita Pekkonen, .et al. KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo, Cell Cycle., 2014, Dec 1; 13(23): 3670-3684. PMID: 25483078

Biological Activity

PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.
Target Value
CDK4/CyclinD3IC50: 9nM
CDK4/CyclinD1IC50: 11nM
CDK6/CyclinD2IC50: 15nM
CDK2/CyclinE2IC50: >10μM
CDK2/CyclinAIC50: >10μM
CDK1/CyclinBIC50: >10μM
CDK5/p25IC50: >10μM
EGFRIC50: >10μM
FGFRIC50: >10μM
PDGFRIC50: >10μM
Insulin ReceptorIC50: >10μM
VEGFRIC50: >10μM
AMPKIC50: >10μM
Chk1IC50: >10μM
CK1IC50: >10μM
CK2IC50: >10μM
c-SrcIC50: >10μM
GSK-3βIC50: >10μM
MAPK2/ERK2IC50: >10μM
PKBIC50: >10μM
PKCIC50: >10μM
PHKIC50: >10μM
SAPK2aIC50: >10μM
SAPK3IC50: >10μM
SAPK4IC50: >10μM
In vitro (25°C) DMSO Warmed: 3 mg/mL (6.19 mM)
Water 30 mg/mL (61.98 mM)
Ethanol Insoluble
In vivo Saline 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.66 mL 103.31 mL 206.61 mL
0.5 mM 4.13 mL 20.66 mL 41.32 mL
1 mM 2.07 mL 10.33 mL 20.66 mL
5 mM 0.41 mL 2.07 mL 4.13 mL

*The above data is based on the productmolecular weight 484.0. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10701
Actions Inhibitor
CAS No. 827022-32-2
Formula C24H29N7O2.HCl
M. Wt 484.0
Purity >98%

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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