Total item
Cart Subtotal
$0.00 Biological Activity
PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.
Targets
| Target | Value |
|---|---|
| CDK4/CyclinD3 | IC50: 9nM |
| CDK4/CyclinD1 | IC50: 11nM |
| CDK6/CyclinD2 | IC50: 15nM |
| CDK2/CyclinE2 | IC50: >10μM |
| CDK2/CyclinA | IC50: >10μM |
| CDK1/CyclinB | IC50: >10μM |
| CDK5/p25 | IC50: >10μM |
| EGFR | IC50: >10μM |
| FGFR | IC50: >10μM |
| PDGFR | IC50: >10μM |
| Insulin Receptor | IC50: >10μM |
| VEGFR | IC50: >10μM |
| AMPK | IC50: >10μM |
| Chk1 | IC50: >10μM |
| CK1 | IC50: >10μM |
| CK2 | IC50: >10μM |
| c-Src | IC50: >10μM |
| GSK-3β | IC50: >10μM |
| MAPK2/ERK2 | IC50: >10μM |
| MAPKAPK2 | IC50: >10μM |
| PKB | IC50: >10μM |
| PKC | IC50: >10μM |
| PHK | IC50: >10μM |
| SAPK2a | IC50: >10μM |
| SAPK3 | IC50: >10μM |
| SAPK4 | IC50: >10μM |
| In vitro (25°C) | DMSO | 3 mg/mL (6.19 mM) | |
| Water | 30 mg/mL (61.98 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | Saline | 20 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.35 mL | 111.73 mL | 223.46 mL |
| 0.5 mM | 4.47 mL | 22.35 mL | 44.69 mL |
| 1 mM | 2.23 mL | 11.17 mL | 22.35 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.47 mL |
*The above data is based on the productmolecular weight 447.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10701 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 447.5 |
| Formula | C24H29N7O2.HCl |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 827022-32-2 |
| SMILES | CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Flavopiridol (Alvocidib)
Flavopiridol (Alvocidib) is a cyclin-dependent kinase inhibitor under clinical development for the treatment of chronic lymphocytic leukemia…
AT7519 HCl
AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhib…
NVP-LCQ195
NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.
Flavopiridol HCl
Flavopiridol HCl is an inhibitor of cyclin-dependent kinases. The (-)-cis form induces apoptosis in particular tumor cells.
P276-00
P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3
Dinaciclib (SCH 727965)
Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 …
CVT-313
CVT-313 is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 (IC50 = 0.5 uM for Cdk2/A and Cdk2/E; 4.2 uM for Cdk1/B; 2…
AT7519
AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhib…
Keywords:buy PD 0332991 HCl (Palbociclib) | PD 0332991 HCl (Palbociclib) Supplier | purchase PD 0332991 HCl (Palbociclib) | PD 0332991 HCl (Palbociclib) cost | PD 0332991 HCl (Palbociclib) manufacturer | order PD 0332991 HCl (Palbociclib) | PD 0332991 HCl (Palbociclib) distributor | buy 827022-32-2| 827022-32-2 Supplier | purchase 827022-32-2 | 827022-32-2 cost | 827022-32-2 manufacturer | order 827022-32-2 | 827022-32-2 distributor
Adooq Quality Guarantee
We promise all products perform as described.