PD 151746

Catalog No.: A14245

Calpain inhibitor

PD 151746

PD 151746 Chemical Structure

CAS NO. 179461-52-0

PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 uM for μ-Calpain, about 20-fold selectivity over m-calpain.

Availability: In stock

Package Price Qty
10 mg
$90.00
25 mg
$180.00
50 mg
$300.00
10mM * 1mL in DMSO
$95.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 uM for μ-Calpain, about 20-fold selectivity over m-calpain.
Targets
μ-Calpain m-calpain
260 nM5.33 μM
In vitro DMSO 47 mg/mL (198.1 mM)
Water <1 mg/mL (<1 mM)
Ethanol 47 mg/mL (198.1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 42.15 mL 210.75 mL 421.5 mL
0.5 mM 8.43 mL 42.15 mL 84.3 mL
1 mM 4.21 mL 21.07 mL 42.15 mL
5 mM 0.84 mL 4.21 mL 8.43 mL

*The above data is based on the productmolecular weight 237.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A14245
Actions Inhibitor
M. Wt 237.25
Formula C11H8FNO2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 179461-52-0
Synonyms PD-151746,PD151746
SMILES C1=CC2=C(C=C1F)C(=CN2)/C=C(/C(=O)O)\S

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