PDE2A-IN-2 is a selective inhibitor of phosphodiesterase type 2A (PDE2A) with a Ki value of 5.49 nM, demonstrating over 100-fold selectivity against other PDE isoforms. This compound serves as a radiolabeled PET tracer, facilitating brain imaging in patients with neurodegenerative diseases by eliciting a signal specifically in PDE2A-rich regions. Its application in neurodegenerative disease research highlights its potential in studying PDE2A's role in pathophysiology.
PDE2A-IN-2 is a selective inhibitor of phosphodiesterase type 2A (PDE2A) with a Ki value of 5.49 nM, demonstrating over 100-fold selectivity against other PDE isoforms. This compound serves as a radiolabeled PET tracer, facilitating brain imaging in patients with neurodegenerative diseases by eliciting a signal specifically in PDE2A-rich regions. Its application in neurodegenerative disease research highlights its potential in studying PDE2A's role in pathophysiology.
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