PDE4-IN-29 is a selective phosphodiesterase 4 (PDE4) inhibitor, with sub-nanomolar potency against PDE4D3, exhibiting IC50 values of less than 5 nM. By inhibiting the degradation of cyclic adenosine monophosphate (cAMP), PDE4-IN-29 effectively elevates intracellular cAMP levels, leading to a reduction in inflammatory cytokine release, including TNF-α. This compound is of great interest for investigating inflammatory diseases such as psoriasis, atopic dermatitis, and chronic obstructive pulmonary disease.
PDE4-IN-29 is a selective phosphodiesterase 4 (PDE4) inhibitor, with sub-nanomolar potency against PDE4D3, exhibiting IC50 values of less than 5 nM. By inhibiting the degradation of cyclic adenosine monophosphate (cAMP), PDE4-IN-29 effectively elevates intracellular cAMP levels, leading to a reduction in inflammatory cytokine release, including TNF-α. This compound is of great interest for investigating inflammatory diseases such as psoriasis, atopic dermatitis, and chronic obstructive pulmonary disease.
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