PDE4-IN-32 is a selective inhibitor of phosphodiesterase 4B (PDE4B) and phosphodiesterase 4D (PDE4D) with IC50 values of 13.7 nM and 23.8 nM, respectively. This compound effectively penetrates the blood-brain barrier and has demonstrated the ability to enhance recovery of motor and cognitive function in mouse models of middle cerebral artery occlusion (MCAO). Additionally, PDE4-IN-32 has been shown to reduce cerebral edema and is a valuable tool for research focused on ischemic stroke.
PDE4-IN-32 is a selective inhibitor of phosphodiesterase 4B (PDE4B) and phosphodiesterase 4D (PDE4D) with IC50 values of 13.7 nM and 23.8 nM, respectively. This compound effectively penetrates the blood-brain barrier and has demonstrated the ability to enhance recovery of motor and cognitive function in mouse models of middle cerebral artery occlusion (MCAO). Additionally, PDE4-IN-32 has been shown to reduce cerebral edema and is a valuable tool for research focused on ischemic stroke.
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