PDE4-IN-34 is a selective phosphodiesterase 4 (PDE4) inhibitor, demonstrating IC50 values of 19 pM and 14 pM for PDE4B1 and PDE4D2, respectively. This compound shows weak inhibitory activity against PDE8A1 (IC50 of 4.092 μM) and exhibits significant selectivity over other PDE subtypes (IC50 > 10 μM). PDE4-IN-34 effectively improves pulmonary function, reduces inflammatory responses, and mitigates lung tissue damage in rat models of chronic obstructive pulmonary disease induced by cigarette smoke and LPS. It serves as a valuable tool for research into PDE4-related pathways in pulmonary disorders.
PDE4-IN-34 is a selective phosphodiesterase 4 (PDE4) inhibitor, demonstrating IC50 values of 19 pM and 14 pM for PDE4B1 and PDE4D2, respectively. This compound shows weak inhibitory activity against PDE8A1 (IC50 of 4.092 μM) and exhibits significant selectivity over other PDE subtypes (IC50 > 10 μM). PDE4-IN-34 effectively improves pulmonary function, reduces inflammatory responses, and mitigates lung tissue damage in rat models of chronic obstructive pulmonary disease induced by cigarette smoke and LPS. It serves as a valuable tool for research into PDE4-related pathways in pulmonary disorders.
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