PDM-631 is a selective inhibitor of phosphodiesterase type 2A (PDE2A) that is both orally active and capable of penetrating the blood-brain barrier. This compound demonstrates potent inhibitory effects, with IC50 values of 1.5 nM against human recombinant PDE2A and 4.2 nM against rat recombinant PDE2A. PDM-631 reliably elevates cGMP levels in the rat cerebral cortex and is valuable for investigating schizophrenia and various neurodegenerative disorders.
PDM-631 is a selective inhibitor of phosphodiesterase type 2A (PDE2A) that is both orally active and capable of penetrating the blood-brain barrier. This compound demonstrates potent inhibitory effects, with IC50 values of 1.5 nM against human recombinant PDE2A and 4.2 nM against rat recombinant PDE2A. PDM-631 reliably elevates cGMP levels in the rat cerebral cortex and is valuable for investigating schizophrenia and various neurodegenerative disorders.
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