Pelitinib-d6 is a stable isotope-labeled variant of Pelitinib, an irreversible inhibitor of the epidermal growth factor receptor (EGFR). Pelitinib demonstrates potent biological activity with an IC50 of 38.5 nM against EGFR and also exhibits moderate inhibition of Src, MEK/ERK, and ErbB2 with IC50 values of 282, 800, and 1255 nM, respectively. This deuterium-labeled compound is valuable for studies requiring precise tracking of drug metabolism and pharmacokinetics, as well as kinetic and mechanistic investigations in cancer research.
Pelitinib-d6 is a stable isotope-labeled variant of Pelitinib, an irreversible inhibitor of the epidermal growth factor receptor (EGFR). Pelitinib demonstrates potent biological activity with an IC50 of 38.5 nM against EGFR and also exhibits moderate inhibition of Src, MEK/ERK, and ErbB2 with IC50 values of 282, 800, and 1255 nM, respectively. This deuterium-labeled compound is valuable for studies requiring precise tracking of drug metabolism and pharmacokinetics, as well as kinetic and mechanistic investigations in cancer research.
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