Pemigatinib-d6 is a deuterated form of Pemigatinib, a selective inhibitor of the fibroblast growth factor receptors (FGFR). This compound exhibits remarkable potency, with IC50 values of 0.4 nM, 0.5 nM, 1.2 nM, and 30 nM against FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Pemigatinib-d6 serves as an important tool in research applications focused on cholangiocarcinoma and other malignancies associated with aberrant FGFR signaling. The stable isotope labeling facilitates comprehensive pharmacokinetic studies and metabolic profiling.
Pemigatinib-d6 is a deuterated form of Pemigatinib, a selective inhibitor of the fibroblast growth factor receptors (FGFR). This compound exhibits remarkable potency, with IC50 values of 0.4 nM, 0.5 nM, 1.2 nM, and 30 nM against FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Pemigatinib-d6 serves as an important tool in research applications focused on cholangiocarcinoma and other malignancies associated with aberrant FGFR signaling. The stable isotope labeling facilitates comprehensive pharmacokinetic studies and metabolic profiling.
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