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Pemigatinib-d6

Stable Isotope

Pemigatinib-d6 is a deuterated form of Pemigatinib, a selective inhibitor of the fibroblast growth factor receptors (FGFR). This compound exhibits remarkable potency, with IC50 values of 0.4 nM, 0.5 nM, 1.2 nM, and 30 nM against FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Pemigatinib-d6 serves as an important tool in research applications focused on cholangiocarcinoma and other malignancies associated with aberrant FGFR signaling. The stable isotope labeling facilitates comprehensive pharmacokinetic studies and metabolic profiling.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2649492-49-7
Applications	Stable Isotope
Formula	C₂₄H₂₁D₆F₂N₅O₄
Molecular Weight	493.54
Synonyms	INCB054828-d6
SMILES	O=C1N(C2=C3C(NC(CN4CCOCC4)=C3)=NC=C2CN1C5=C(C(OC([2H])([2H])[2H])=CC(OC([2H])([2H])[2H])=C5F)F)CC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.