PF-03814735

Catalog No.: A11171

Aurora A/B Kinase inhibitor

PF-03814735

PF-03814735 Chemical Structure

CAS NO. 942487-16-3

PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.

Availability: Out of stock

Package Price
5 mg
$90.00
10 mg
$160.00
50 mg
$600.00
100 mg
$1,200.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.
Targets
Aurora A Aurora B FLT1 FAK TrkA
0.8 nM5 nM10 nM22 nM30 nM
In vitro (25°C) DMSO 0.4 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.08 mL 105.38 mL 210.76 mL
0.5 mM 4.22 mL 21.08 mL 42.15 mL
1 mM 2.11 mL 10.54 mL 21.08 mL
5 mM 0.42 mL 2.11 mL 4.22 mL

*The above data is based on the productmolecular weight 474.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A11171
Actions Inhibitor
M. Wt 474.48
Formula C23H25F3N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 942487-16-3
Synonyms PF03814735
SMILES CC(=O)NCC(=O)N1[[email protected]]2CC[[email protected]@H]1C3=C2C=CC(=C3)NC4=NC=C(C(=N4)NC5CCC5)C(F)(F)F

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