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$0.00 Biological Activity
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.
Targets
| Aurora A | Aurora B | FLT1 | FAK | TrkA |
| 0.8 nM | 5 nM | 10 nM | 22 nM | 30 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.08 mL | 105.38 mL | 210.76 mL |
| 0.5 mM | 4.22 mL | 21.08 mL | 42.15 mL |
| 1 mM | 2.11 mL | 10.54 mL | 21.08 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.22 mL |
*The above data is based on the productmolecular weight 474.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11171 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 942487-16-3 |
| Formula | C23H25F3N6O2 |
| M. Wt | 474.48 |
| Purity | >98% |
| Synonyms | PF03814735 |
| SMILES | CC(=O)NCC(=O)N1[[email protected]]2CC[[email protected]@H]1C3=C2C=CC(=C3)NC4=NC=C(C(=N4)NC5CCC5)C(F)(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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