PF-05020182 is an orally active Kv7 channel activator that specifically targets human Kv7.2/7.3, Kv7.4, and Kv7.3/7.5 channels, with EC50 values of 334, 625, and 588 nM, respectively. This compound demonstrates significant anticonvulsant activity in rat models of corneal electric shock-induced tonic seizures. Additionally, PF-05020182 is capable of crossing the blood-brain barrier, making it a valuable tool for neurological research applications.
PF-05020182 is an orally active Kv7 channel activator that specifically targets human Kv7.2/7.3, Kv7.4, and Kv7.3/7.5 channels, with EC50 values of 334, 625, and 588 nM, respectively. This compound demonstrates significant anticonvulsant activity in rat models of corneal electric shock-induced tonic seizures. Additionally, PF-05020182 is capable of crossing the blood-brain barrier, making it a valuable tool for neurological research applications.
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